The most expensive painting of Jesus Christ is "Salvator Mundi" by Leonardo da Vinci. It depicts Jesus Christ as the Savior of the World, with his right hand raised in blessing and his left hand holding a crystal orb. The painting is renowned for its exquisite detail, masterful composition, and profound spiritual presence. It sold for a record-breaking $450.3 million in 2017, making it the most expensive painting ever sold at auction.